Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody
Catalog # BAF470 | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Summary for Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody
Immunogen
Ile22-Ala109
Accession # Q3U1E8
Specificity
Clonality
Host
Isotype
Applications for Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody
Western Blot
Sample: Recombinant Mouse CXCL13/BLC/BCA‑1 (Catalog # 470-BC)
Mouse CXCL13/BLC/BCA-1 Sandwich Immunoassay
Reviewed Applications
Read 1 review rated 4 using BAF470 in the following applications:
Published Applications
Read 5 publications using BAF470 in the following applications:
Formulation, Preparation and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCL13/BLC/BCA-1
CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Mouse BCA-1 cDNA encodes a precursor protein of 109 amino acid residues with a putative leader sequence of 21 residues. Mature mouse BCA-1 shares 64% amino acid sequence similarity with the human protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.
Product Documents for Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody
Product Specific Notices for Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody
For research use only
Citations for Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody (5)
Citations are publications that use Bio-Techne products. Selected citations for Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody include:
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Species: Mouse
Sample Types: Whole Tissue
Applications: IHCHW Cheng et al. (2022-04-19), Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function Nature Communications, 2022-013(1):2027.
PMID: 35440118 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHCNakagawa R et al. (2013-03-04), Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture. J Immunol, 2013-0190(7):3309-18.
PMID: 23460741 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHCBaptista A et al. (2012-09-19), Colonic patch and colonic SILT development are independent and differentially regulated events. Mucosal Immunol, 2012-06(3):511-21.
PMID: 22990625 -
Species: Mouse
Sample Types: Plasma
Applications: Luminex DevelopmentZhang M et al. (2012-01-25), Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine, 2012-058(2):169-77.
PMID: 22277799 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-FrKatakai T et al. (2008-11-01), Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J. Immunol., 2008-1181(9):6189-200.
PMID: 18941209
There are no citations that match your criteria.
Customer Reviews for Mouse CXCL13/BLC/BCA‑1 Biotinylated Antibody (1)
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.