CD200 Receptor 2 (CD200R2), or CD200R1L, is a type I transmembrane receptor for the CD200 cell surface glycoprotein. Mature CD200R2 consists of an extracellular domain (ECD) containing an Ig-like V-type domain and an Ig-like C2-type domain, a transmembrane segment and a short cytoplasmic domain. The ECD of mouse CD200R2 shares a 76% and 63% amino acid (aa) identity with the rat and human ECD, respectively. CD200R2 is strongly expressed on resting mast cells but deceased upon activation via Fc epsilonR1. It is also observed on monocytes, bone marrow-derived dendritic cells and TH2 cells (1, 2, 4). It has been demonstrated CD200R2 can interact with CD200 (3) and signal through adaptor protein, DAP12, via its lysine residue in the transmembrane region (2). In addition, it has been reported CD200 and CD200R2 interaction alters dendritic cell differentiation and enhances induction of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in mouse transplant model (5).

References

Wright, G. et al. (2003) J. Immunol. 171:3034.
Voehringer, D. (2004) J. Biol. Chem. 279(52):54117.
Gorczynski, R. et al. (2004) J. Immunol. 172:7744.
Minas, K. (2006) Crit Rev Immunol 26(3):213.
Gorczynski, R. et al. (2008) J. Immunol. 180(9):5946.

Long Name

CD200 Receptor 1 Like

Alternate Names

CD200R2, CD200RLa

Entrez Gene IDs

344807 (Human); 271375 (Mouse); 501779 (Rat)

Gene Symbol

CD200R1L

UniProt

Q6XJV6.1

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This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Mouse CD200R1L Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB10198AFP680

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Background: CD200R1L