Human/Mouse SOX2 APC-conjugated Antibody

Name: Human/Mouse SOX2 APC-conjugated Antibody
Brand: R&D Systems
SKU: IC2018A
Price: 411 USD

R&D Systems, Inc. a Bio-Techne Brand

Catalog # IC2018A

Citations (2)

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Species Reactivity:	Human, Mouse
Immunogen:	E. coli-derived recombinant human SOX2 Gly135-Met317 Accession # P48431
Applications:	Flow Cytometry
Label:	Allophycocyanin (Excitation=620-650 nm, Emission=660-670 nm)
Source:	Monoclonal Mouse IgG_2A Clone # 245610
Specificity:	Detects human and mouse SOX2 in Western blots.

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Applications for Human/Mouse SOX2 APC-conjugated Antibody

	Recommended Concentration	Sample
Intracellular Staining by Flow Cytometry	10 µL/10⁶ cells	See below

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Scientific Data Examples for Human/Mouse SOX2 APC-conjugated Antibody

	Intracellular Staining by Flow Cytometry Detection of SOX2 in NTera‑2 Human Cell Line by Flow Cytometry. NTera-2 human testicular embryonic carcinoma cell line was stained with Mouse Anti-Human/Mouse SOX2 APC-conjugated Monoclonal Antibody (Catalog # IC2018A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.

Formulation, Preparation and Storage

Purification	Protein A or G purified from hybridoma culture supernatant
Formulation	Supplied in a saline solution containing BSA and Sodium Azide.
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Background: SOX2

SOX2 belongs to the SOX (SRY-like HMG box) family of transcription factors with diverse roles in development. SOX2 functions in specifying the first three lineages present at implantation and in regulating proliferation and differentiation in the developing peripheral nervous system (1-5).

Item	Value
References	Graham, V. et al. (2003) Neuron 39:749. Avilion, A.A. et al. (2003) Genes Dev. 17:126. Kishi, M. et al. (2000) Development 127:791. Yuan, H. et al. (1995) Genes Dev. 9:2635. Uwanogho, D. et al. (1995) Mech. Dev. 49:23. Stevanovic, M. (2003) Mol. Biol. Rep. 30:127.
Long Name	Transcription Factor SOX2
Entrez Gene IDs	6657 (Human)
Alternate Names	ANOP3, MCOPS3, MGC2413, SOX2, SRY (sex determining region Y)-box 2, SRY-related HMG-box gene 2, transcription factor SOX-2, transcription factor SOX2

Citations for Human/Mouse SOX2 APC-conjugated Antibody (2)

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Citations are publications that use Bio-Techne products. Selected citations for Human/Mouse SOX2 APC-conjugated Antibody include:

Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry

Huijbers I et al. (2014), Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med, 6(2):212-25.
PMID: 24401838
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Liu C et al. (2011), Chemokine receptor CXCR3 promotes growth of glioma. Carcinogenesis, 32(2):129-37.
PMID: 21051441

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Product Documents for Human/Mouse SOX2 APC-conjugated Antibody

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Human/Mouse SOX2 APC-conjugated Antibody

R&D Systems, Inc. a Bio-Techne Brand

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Applications for Human/Mouse SOX2 APC-conjugated Antibody

Scientific Data Examples for Human/Mouse SOX2 APC-conjugated Antibody

Intracellular Staining by Flow Cytometry