Human mGluR1a Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB4836AFP488

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FAB4836AFP488-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 511622

View all mGluR1 Antibodies »

Product Specifications

Specificity

Detects human mGluR1a in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Background: mGluR1

Metabotropic glutamate receptor 1 (mGluR1 alpha) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with Gq-like proteins, mobilizes intracellular Ca++, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19‑592). The ECD binds glutamate and forms either a covalent homodimer, or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33‑522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1.

Long Name

Metabotropic Glutamate Receptor 1

Alternate Names

GPRC1A, GRM1

Entrez Gene IDs

2911 (Human); 14816 (Mouse); 24414 (Rat)

Gene Symbol

GRM1

UniProt

Q13255

Additional mGluR1 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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