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Human Jarid1A/KDM5A Alexa Fluor 532 MAb (Clone 1102542)

R&D Systems, part of Bio-Techne | Catalog # FAB11705X

R&D Systems, part of Bio-Techne
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FAB11705X-100UG

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor 532 (Excitation = 534 nm, Emission = 553 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 1102542

Product Specifications

Immunogen

E. coli-derived recombinant human Jarid1A/KDM5A
Lys127-Ser287
Accession # P29375

Specificity

Detects recombinant human Jarid1A/KDM5a protein in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human Jarid1A/KDM5A Alexa Fluor 532 MAb (Clone 1102542)

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Jarid1A

Jarid1A (also known as KDM5A) is a protein of approximately 175kDa that belongs to the Jumonji/ARID1 (JARID) protein family. It functions primarily as a lysine demethylase, involved in the regulation of histone H3 lysine 4 (H3K4) demethylation, thereby playing a crucial role in chromatin remodeling and epigenetic regulation. Jarid1A is implicated in multiple biological processes, including cell cycle progression, differentiation, and development. Dysregulation of Jarid1A is associated with various pathologies, particularly its overexpression in several types of cancer, where it contributes to tumorigenesis, cancer cell proliferation, and metastasis. It is also linked to altered gene expression profiles in neurological disorders. The role of Jarid1A in transcriptional regulation highlights its potential as a therapeutic target and biomarker for cancer and other diseases involving epigenetic dysregulation.

References

  1. Harmeyer KM, Facompre ND, Herlyn M, Basu D. JARID1 Histone Demethylases: Emerging Targets in Cancer. Trends Cancer. 2017 Oct;3(10):713-725. doi: 10.1016/j.trecan.2017.08.004. Epub 2017 Sep 12. PMID: 28958389; PMCID: PMC5679451. 
  2. Yang GJ, Zhu MH, Lu XJ, Liu YJ, Lu JF, Leung CH, Ma DL, Chen J. The emerging role of KDM5A in human cancer. J Hematol Oncol. 2021 Feb 17;14(1):30. doi: 10.1186/s13045-021-01041-1. PMID: 33596982; PMCID: PMC7888121.

Long Name

Lysine-specific demethylase 5A

Alternate Names

EC 1.14.11.67, KDM5A, RBBP-2, RBBP2, RBP2

Entrez Gene IDs

5927 (Human); 214899 (Mouse)

Gene Symbol

KDM5A

UniProt

Additional Jarid1A Products

Product Documents for Human Jarid1A/KDM5A Alexa Fluor 532 MAb (Clone 1102542)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Jarid1A/KDM5A Alexa Fluor 532 MAb (Clone 1102542)


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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