Human IL-4R alpha PE-conjugated Antibody

Name: Human IL-4R alpha PE-conjugated Antibody
Brand: R&D Systems
SKU: FAB230P

R&D Systems, Inc. a Bio-Techne Brand

Catalog # FAB230P

Citations (5)

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Species Reactivity:	Human
Immunogen:	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑4 R Gly24-His232 Accession # P24394
Applications:	Flow Cytometry
Label:	Phycoerythrin (Excitation=488 nm, Emission=565-605 nm)
Source:	Monoclonal Mouse IgG_2A Clone # 25463
Specificity:	Detects human IL‑4 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha, rhIL-5 R beta, rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed.

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Applications for Human IL-4R alpha PE-conjugated Antibody

	Recommended Concentration	Sample
Flow Cytometry	10 µL/10⁶ cells	See below

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Scientific Data Examples for Human IL-4R alpha PE-conjugated Antibody

	Flow Cytometry Detection of IL‑4 R alpha in Daudi Human Cell Line by Flow Cytometry. Daudi human Burkitt's lymphoma cell line was stained with Mouse Anti-Human IL-4 Ra PE-conjugated Monoclonal Antibody (Catalog # FAB230P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Formulation, Preparation and Storage

Purification	Protein A or G purified from ascites
Formulation	Supplied in a saline solution containing BSA and Sodium Azide.
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Background: IL-4R alpha

Interleukin 4 receptor (IL-4 R) is the transmembrane ligand binding subunit of the heterodimeric IL-4 receptor complex. In the type I receptor complex, IL-4 R associates with the common gamma chain, whereas in the type II receptor complex, it associates with IL-13 R alpha 1. IL-4 R is expressed by B cells, T cells, monocytes and macrophages.

Item	Value
Long Name	Interleukin 4 Receptor alpha
Entrez Gene IDs	3566 (Human); 16190 (Mouse)
Alternate Names	CD124, CD124 antigen, IL-4 R alpha, IL-4 receptor subunit alpha, IL-4R alpha, IL-4R subunit alpha, IL-4R-alpha, IL-4Ra, IL4R, IL4R alpha, IL4RACD124, interleukin 4 receptor, interleukin-4 receptor alpha chain, interleukin-4 receptor subunit alpha

Citations for Human IL-4R alpha PE-conjugated Antibody (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Human IL-4R alpha PE-conjugated Antibody include:

Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

S Magri et al. (2021), Sustained Accumulation of Blood-Derived Macrophages in the Immune Microenvironment of Patients with Recurrent Glioblastoma after Therapy Cancers, 13(24).
PMID: 34944798
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

AB Guimarães- et al. (2017), Neutrophil Extracellular Traps Reprogram IL-4/GM-CSF-Induced Monocyte Differentiation to Anti-inflammatory Macrophages Front Immunol, 8(0):523.
PMID: 28567039
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Occhipinti S et al. (2014), Chimeric rat/human HER2 efficiently circumvents HER2 tolerance in cancer patients. Clin Cancer Res, 20(11):2910-21.
PMID: 24668647
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Mandruzzato S et al. (2009), IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients. J. Immunol., 182(10):6562-8.
PMID: 19414811
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry

Maki K et al. (2008), MEK1/2 induces STAT5-mediated germline transcription of the TCRgamma locus in response to IL-7R signaling. J. Immunol., 181(1):494-502.
PMID: 18566415

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Showing 1 - 5 of 5 citations Showing All

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Human IL-4R alpha PE-conjugated Antibody

R&D Systems, Inc. a Bio-Techne Brand

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Applications for Human IL-4R alpha PE-conjugated Antibody

Scientific Data Examples for Human IL-4R alpha PE-conjugated Antibody

Flow Cytometry