Human CXCL13/BLC/BCA‑1 Biotinylated Antibody
Catalog # BAF801 | R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Summary for Human CXCL13/BLC/BCA‑1 Biotinylated Antibody
Immunogen
Val23-Arg94
Accession # Q53X90
Specificity
Clonality
Host
Isotype
Applications for Human CXCL13/BLC/BCA‑1 Biotinylated Antibody
Western Blot
Sample: Recombinant Human CXCL13/BLC/BCA‑1 (Catalog # 801-CX)
Human CXCL13/BLC/BCA-1 Sandwich Immunoassay
Published Applications
Read 3 publications using BAF801 in the following applications:
Formulation, Preparation and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCL13/BLC/BCA-1
CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. BCA-1 cDNA encodes a protein of 109 amino acid residues with a leader sequence of 22 residues. Mature human BCA-1 shares 64% amino acid sequence similarity with the mouse protein and 23 - 34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.
Product Documents for Human CXCL13/BLC/BCA‑1 Biotinylated Antibody
Product Specific Notices for Human CXCL13/BLC/BCA‑1 Biotinylated Antibody
For research use only
Citations for Human CXCL13/BLC/BCA‑1 Biotinylated Antibody (3)
Citations are publications that use Bio-Techne products. Selected citations for Human CXCL13/BLC/BCA‑1 Biotinylated Antibody include:
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Species: Human
Sample Types: Whole Tissue
Applications: IHC-FrHoorweg K et al. (2015-09-16), A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells. J Immunol, 2015-0195(9):4257-63.
PMID: 26378073 -
Species: Human
Sample Types: Whole Tissue
Applications: IHC-PCagigi A et al. (2008-09-09), Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood, 2008-0112(12):4401-10.
PMID: 18780835 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA DevelopmentLisignoli G et al. (2006-05-01), Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J. Cell. Physiol., 2006-0207(2):364-73.
PMID: 16331675
There are no citations that match your criteria.
Reconstitution Calculator
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