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Human CD57 Alexa Fluor 532 MAb (Clone 1088014)

R&D Systems, part of Bio-Techne | Catalog # FAB11708X

R&D Systems, part of Bio-Techne
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FAB11708X-100UG

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Flow Cytometry

Label

Alexa Fluor 532 (Excitation = 534 nm, Emission = 553 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1088014

Product Specifications

Immunogen

Whole Cell
Accession # Q9P2W7

Specificity

Detects the CD57 carbohydrate epitope in Human PBMCs

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human CD57 Alexa Fluor 532 MAb (Clone 1088014)

Application
Recommended Usage

Flow Cytometry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CD57

CD57 is a glycoprotein with a molecular weight of approximately 100 kDa, classified within the group of adhesion molecules. It plays a significant role in immune regulation and cellular interactions, particularly influencing the functioning of natural killer (NK) cells and certain T-cells. CD57 is heavily involved in the biological processes of cytotoxic activity and immune response modulation. Altered levels of CD57 expression have been associated with several pathological conditions, including chronic infections, autoimmune diseases, and various malignancies. Crucially, CD57 serves as a key biomarker for immune senescence and the monitoring of NK cell and T-cell activities in diseases such as HIV and cancer.

References

1. Kared H, Martelli S, Ng TP, Pender SL, Larbi A. CD57 in human natural killer cells and T-lymphocytes. Cancer Immunol Immunother. 2016 Apr;65(4):441-52. doi: 10.1007/s00262-016-1803-z. Epub 2016 Feb 5. PMID: 26850637; PMCID: PMC11029668. 
2. Elias Junior E, Gubert VT, Bonin-Jacob CM, Puga MAM, Gouveia CG, Sichinel AH, Tozetti IA. CD57 T cells associated with immunosenescence in adults living with HIV or AIDS. Immunology. 2024 Jan;171(1):146-153. doi: 10.1111/imm.13707. Epub 2023 Oct 25. PMID: 37880915. 
3. Lian J, Yue Y, Yu W, Zhang Y. Immunosenescence: a key player in cancer development. J Hematol Oncol. 2020 Nov 10;13(1):151. doi: 10.1186/s13045-020-00986-z. Erratum in: J Hematol Oncol. 2025 Mar 5;18(1):25. doi: 10.1186/s13045-025-01682-6. PMID: 33168037; PMCID: PMC7653700.

Long Name

Cluster of Differentiation 57

Alternate Names

Human Natural Killer-1, L2, LEU-7

Entrez Gene IDs

27087 (Human); 76898 (Mouse); 117108 (Rat)

Gene Symbol

B3GAT1

UniProt

Additional CD57 Products

Product Documents for Human CD57 Alexa Fluor 532 MAb (Clone 1088014)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human CD57 Alexa Fluor 532 MAb (Clone 1088014)


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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