Human beta-Catenin PE-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # IC13292P

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IC13292P
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Intracellular Staining by Flow Cytometry

Cited:

Flow Cytometry

Label

Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 196624

View all beta-Catenin Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human beta-Catenin
Ala2-Leu781
Accession # P35222

Specificity

Detects human, mouse, and rat beta-Catenin in Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human beta-Catenin PE-conjugated Antibody

Detection of beta-Catenin antibody in HeLa Human Cell Line antibody by Flow Cytometry.

Detection of beta‑Catenin in HeLa Human Cell Line by Flow Cytometry.

HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human beta-Catenin PE-conjugated Monoclonal Antibody (Catalog # IC13292P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Intracellular Molecules.

Applications for Human beta-Catenin PE-conjugated Antibody

Application
Recommended Usage

Intracellular Staining by Flow Cytometry

10 µL/106 cells
Sample: HeLa human cervical epithelial carcinoma cell line

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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: beta-Catenin

beta-Catenin is a 94-96 kDa member of the beta-Catenin family, armadillo-repeat superfamily of intracellular molecules. Human beta-Catenin is 781 amino acids (aa) in length and contains three basic regions; there is a "flexible" N-terminus (aa 1-110) that undergoes phosphorylation, O-linked glycosylation, acetylation and ubiquitination, a central region (aa 14-670) that contains 12 armadillo-like repeats and engages in protein-protein interaction, and a "flexible" C-terminus that also undergoes phosphorylation. beta-Catenin is widely, if not ubiquitously expressed, being found in endothelial cells, NKT cells, cortical neurons, neural stem cells, osteoblasts, fibroblasts, skeletal muscle cells, and Tregs. beta-Catenin is perhaps best known as a facilitator for Wnt signaling. In this context, and in the absence of Wnt signaling, non-nuclear or E-Cadherin-associated beta-Catenin is continually synthesized and degraded via a phosphorylation-dependent program. Upon Wnt engagement of its LPR:Fzd receptor complex, phosphorylation stops, allowing for an increase in it half-life and translocation into the nucleus. Here, it binds to TCF, generating a gene-activating transcriptional complex. Notably, Wnt signaling has been described as being  beta-Catenin and Ca++/non-beta -Catenin based. It now appears they work in tandem, with Ca++ mobilization facilitating the translocation of beta-Catenin across the nuclear membrane. Human and mouse full-length beta-Catenin shows 99% aa sequence identity.

Alternate Names

bCatenin, CTNNB1

Entrez Gene IDs

1499 (Human); 12387 (Mouse); 84353 (Rat)

Gene Symbol

CTNNB1

UniProt

P35222

Additional beta-Catenin Products

Product Documents for Human beta-Catenin PE-conjugated Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Human beta-Catenin PE-conjugated Antibody

For research use only

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