Vitamin D BP Products
Vitamin D binding protein (VitD BP), also known as DBP and Gc-globulin, is a 58 kDa glycoprotein that circulates at high concentration in the serum and serves as a carrier protein for vitamin D. The transport of vitamin D by VitD BP is important for the function of a wide variety of tissues. VitD BP binds both the 25(OH) and the hormonally active 1,25(OH)2 forms of vitamin D. VitD BP is primarily expressed in hepatocytes and to a lesser extent in the kidney. It delivers vitamin D into cells by Megalin-mediated endocytosis. A selectively deglycosylated form of VitD BP known as macrophage activating factor (MAF) blocks the angiogenic effects of FGF basic, VEGF, and Angiopoietin 2. VitD BP enhances the chemotaxis of monocytes and neutrophils to the activated complement component C5a or C5a des Arg (a C-terminally processed form of C5a). The chemotactic cofactor property of VitD BP is eliminated by binding to 1,25(OH)2 vitamin D, but it is not altered by binding to 25(OH) vitamin D or actin.
13 results for "Vitamin D BP" in Products
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Vitamin D BP Products
Vitamin D binding protein (VitD BP), also known as DBP and Gc-globulin, is a 58 kDa glycoprotein that circulates at high concentration in the serum and serves as a carrier protein for vitamin D. The transport of vitamin D by VitD BP is important for the function of a wide variety of tissues. VitD BP binds both the 25(OH) and the hormonally active 1,25(OH)2 forms of vitamin D. VitD BP is primarily expressed in hepatocytes and to a lesser extent in the kidney. It delivers vitamin D into cells by Megalin-mediated endocytosis. A selectively deglycosylated form of VitD BP known as macrophage activating factor (MAF) blocks the angiogenic effects of FGF basic, VEGF, and Angiopoietin 2. VitD BP enhances the chemotaxis of monocytes and neutrophils to the activated complement component C5a or C5a des Arg (a C-terminally processed form of C5a). The chemotactic cofactor property of VitD BP is eliminated by binding to 1,25(OH)2 vitamin D, but it is not altered by binding to 25(OH) vitamin D or actin.
13 results for "Vitamin D BP" in Products
Simple Plex Human Vitamin D BP assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Sensitivity : | 0.338 ng/mL |
Assay Range : | 6.25 - 100 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
Applications : | ELISA |
Assay Range : | 187 - 3,000 pg/mL |
Applications : | ELISA |
Source : | NS0 |
Accession # : | P02774 |
Applications : | Bioactivity |
Assay Range : | 469 - 15,000 pg/mL |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #359501 |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Sheep IgG |
Applications : | Simple Western, Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #884704 |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG1 Clone #884706 |
Applications : | ELISA |
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.