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TRAILR4/TNFRSF10D Products

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAILR1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAILR1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAILR1 and R2. TRAILR3 is membrane-associated via GPI linkage. TRAILR4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAILR1 and R2, OPG has a DD motif but is a soluble protein.

22 results for "TRAILR4/TNFRSF10D" in Products

TRAILR4/TNFRSF10D Products

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAILR1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAILR1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAILR1 and R2. TRAILR3 is membrane-associated via GPI linkage. TRAILR4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAILR1 and R2, OPG has a DD motif but is a soluble protein.

22 results for "TRAILR4/TNFRSF10D" in Products

Catalog #: FAB633RT
Flow

Recombinant Monoclonal Antibody.

BA
Catalog #: FAB633RN
Flow

Recombinant Monoclonal Antibody.

Flow, CyTOF-ready, Neut
WB, ELISA, Flow, IHC, CyTOF-ready, Neut
Catalog #: FAB633N
Flow
Catalog #: FAB633RU
Flow

Recombinant Monoclonal Antibody.

ELISA, Flow, CyTOF-ready, Neut

Recombinant Monoclonal Antibody.

Catalog #: FAB633R
Flow
Catalog #: FAB633V
Flow
WB
Catalog #: FAB633RR
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB633RG
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB633RS
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB633RV
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB633S
Flow
Catalog #: FAB633U
Flow
Catalog #: FAB633T
Flow
Catalog #: RDC1564
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