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TIMP-4: Antibodies
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
4 results for "TIMP-4 Primary Antibodies" in Products
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TIMP-4: Antibodies
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
4 results for "TIMP-4 Primary Antibodies" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #153934 |
| Applications : | ELISA Capture, Immunohistochemistry, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA Detection, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA, Western Blot |
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #866106R |
| Applications : | ELISA |
