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SIRP alpha/CD172a Products
Signal regulatory protein alpha (SIRP alpha, designated CD172a), also called SHPS-1 (SHP substrate 1), BIT (Brain Ig-like molecule with Tyrosine-based activation motifs) and previously, MyD-1 (Myeloid/Dendritic-1), is a transmembrane glycoprotein belonging to the SIRP/SHPS (CD172) family within the immunoglobulin superfamily. SIRP alpha contains cytoplasmic ITIM domains and produces negative regulatory signals. Through adhesion to CD47/IAP (integrin-associated protein), SIRP alpha inhibits clearance of CD47high young erythrocytes and platelets and promotes macrophage fusion during osteoclastogenesis. SIRP alpha recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production.
42 results for "SIRP alpha/CD172a" in Products
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SIRP alpha/CD172a Products
Signal regulatory protein alpha (SIRP alpha, designated CD172a), also called SHPS-1 (SHP substrate 1), BIT (Brain Ig-like molecule with Tyrosine-based activation motifs) and previously, MyD-1 (Myeloid/Dendritic-1), is a transmembrane glycoprotein belonging to the SIRP/SHPS (CD172) family within the immunoglobulin superfamily. SIRP alpha contains cytoplasmic ITIM domains and produces negative regulatory signals. Through adhesion to CD47/IAP (integrin-associated protein), SIRP alpha inhibits clearance of CD47high young erythrocytes and platelets and promotes macrophage fusion during osteoclastogenesis. SIRP alpha recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production.
42 results for "SIRP alpha/CD172a" in Products
| Assay Range : | 62.5 - 4,000 pg/mL |
| Applications : | ELISA |
Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47
| Chemical Name : | 6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine |
| Purity : | ≥98% (HPLC) |
| Source : | CHO |
| Accession # : | NP_542970.1 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #602411 |
| Applications : | CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #772734 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #772734 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #772734 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #602407 |
| Applications : | ELISA |
Biotinylated via amines
| Source : | CHO |
| Accession # : | NP_542970 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | Simple Western, Western Blot |
| Source : | NS0 |
| Accession # : | P97710 |
| Applications : | Bioactivity |
| Source : | NS0 |
| Accession # : | P97797 |
| Applications : | Bioactivity |
| Source : | NS0 |
| Accession # : | NP_001271679 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #602411 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #602411 |
| Applications : | Flow Cytometry |
| Source : | CHO |
| Accession # : | NP_542970.1 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #772734 |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #772734 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #602411 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #602411 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #772734 |
| Applications : | Flow Cytometry |
