SIRP alpha/CD172a Antibody (DH59B)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61014

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NBP2-61014
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Key Product Details

Species Reactivity

Validated:

Human, Porcine, Alpaca, Bison, Bovine, Canine, Equine, Feline, Ferret, Llama, Mink, Sheep, Water Buffalo

Cited:

Porcine

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # DH59B

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all SIRP alpha/CD172a Antibodies »

Product Specifications

Immunogen

Leukocytes from: Dog, bovine, horse

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Description

This monoclonal antibody is made in ascites form using mice. The ascites is collected and centrifuged to remove cells and large particles. The ascitic fluid is purified further by filtration through sequential filters with the last filter at 2 um. The concentration of the monoclonal antibody present in the ascites is determined with commercial radial immunodiffusion kits (1mg/ml).

Scientific Data Images for SIRP alpha/CD172a Antibody (DH59B)

Flow Cytometry: SIRP alpha/CD172a Antibody (DH59B) [NBP2-61014]

Flow Cytometry: SIRP alpha/CD172a Antibody (DH59B) [NBP2-61014]

Flow Cytometry: SIRP alpha/CD172a Antibody (DH59B) [NBP2-61014] - Obtained with bovine leukocytes

Applications for SIRP alpha/CD172a Antibody (DH59B)

Application
Recommended Usage

Flow Cytometry

1:10 - 1:1000

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Ascites

Preservative

0.09% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SIRP alpha/CD172a

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6) and p84 (7). SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2 (1,2,5,8). SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,8).

Long Name

Signal-regulatory Protein alpha

Alternate Names

BIT, CD172a, MFR, MYD-1, SHPS1, SIRPA

Gene Symbol

SIRPA

Additional SIRP alpha/CD172a Products

Product Documents for SIRP alpha/CD172a Antibody (DH59B)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for SIRP alpha/CD172a Antibody (DH59B)

This monoclonal antibody is made in ascites form using mice. The ascites is collected and centrifuged to remove cells and large particles. The ascitic fluid is purified further by filtration through sequential filters with the last filter at 2 um. The concentration of the monoclonal antibody present in the ascites is determined with commercial radial immunodiffusion kits (1mg/ml).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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