Skip to main content

Siglec-6/CD327 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

25 results for "Siglec-6/CD327" in Products

Siglec-6/CD327 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

25 results for "Siglec-6/CD327" in Products

Flow, CyTOF-ready
Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

ELISA
WB, ELISA
Bind
IHC
Catalog #: FAB2859S
Flow
Catalog #: RDC1157
ELISA

Recombinant Monoclonal Antibody.

Catalog #: FAB2859RN
Flow

Recombinant Monoclonal Antibody

Catalog #: FAB2859R
Flow
Catalog #: FAB2859RG
Flow

Recombinant Monoclonal Antibody

Catalog #: FAB2859RU
Flow

Recombinant Monoclonal Antibody

Catalog #: FAB2859RT
Flow

Recombinant Monoclonal Antibody

Catalog #: FAB2859RR
Flow

Recombinant Monoclonal Antibody

Catalog #: FAB2859RV
Flow

Recombinant Monoclonal Antibody

Catalog #: FAB2859RS
Flow

Recombinant Monoclonal Antibody

Catalog #: FAB2859U
Flow
Flow
Flow
Catalog #: FAB2859V
Flow
Catalog #: RDC1606
/ 1
Results Per Page
5 10 25 50