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182 results for "SHP-2" in Products

SHP-2 Products

The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.

Protein tyrosine phosphatase inhibitor

Chemical Name: Trisodium vanadate
Protein tyrosine phosphatase inhibitor
Source: E. coli
Accession #: NP_002825.3
Applications: EnzAct
R&D Systems Recombinant Proteins and Enzymes

Substrate for PTP1B, TC-PTP, SHP-2, and Tyrosine Phosphatase

Reactivity: Human
Details: Mouse IgG1 Monoclonal Clone #6D9
Applications: IHC, WB, ELISA, ICC/IF, Flow, +1 More
Western Blot: SHP-2/PTPN11 Antibody (6D9)BSA Free [NBP2-37454]
(6)
Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Polyclonal
Applications: IHC, WB, KO
Immunohistochemistry-Paraffin: SHP-2/PTPN11 Antibody [NBP1-33064]
(5)

Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies

The Human Phospho-Immunoreceptor Array detects multiple tyrosine phosphorylated immunoreceptors in lysates prepared from cells activated by antibody mediated cross-linking of cell-surface immunoreceptors.
(2)
Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Polyclonal
Applications: WB, ELISA, ICC/IF, IP, KO
Western Blot: SHP-2/PTPN11 AntibodyAzide and BSA Free [NBP3-03486]
(4)
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