Skip to main content

7 results for "Protein Dimerizers Small Molecules and Peptides" in Products

Protein Dimerizers: Small Molecules and Peptides

Protein dimerizers, also known as chemical inducers of dimerization (CIDs), are chemical compounds which bind two different proteins and bring them into close proximity solely in the presence of the dimerizer. They are commonly used to build protein complexes.

This is sometimes a natural process, as is the case with rapamycin, an antifungal compound that binds both FK506-binding protein (FKBP12) and FKBP-rapamycin binding protein (FRB). Another example of a natural dimerizer is gibberellin ...

Show More

mTOR inhibitor; immunosuppressant

Chemical Name: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Purity: ≥98% (HPLC)
mTOR inhibitor; immunosuppressant

Chemical inducer of protein dimerization; active in vivo

Chemical Name: 2,2'-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
Purity: ≥98% (HPLC)
Chemical inducer of protein dimerization; active in vivo

Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags

Chemical Name: (R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98% (HPLC)
Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags

Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins

Chemical Name: (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98% (HPLC)
Heterobifunctional compound for nuclear import of PKBP F36V tagged proteins

Chemical inducer of protein dimerization; active in vivo

Chemical Name: 2,2'-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
Purity: ≥98% (HPLC)
Chemical inducer of protein dimerization; active in vivo

Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Chemical Name: 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
Purity: ≥98% (HPLC)
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Inducer of autophagy via interaction of p62 and LC3

Chemical Name: 2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride
Purity: ≥98% (HPLC)
Inducer of autophagy via interaction of p62 and LC3
Results Per Page
5 10 25 50
/ 1