7 results for "Protein Dimerizers Small Molecules and Peptides" in Products
Protein Dimerizers: Small Molecules and Peptides
Protein dimerizers, also known as chemical inducers of dimerization (CIDs), are chemical compounds which bind two different proteins and bring them into close proximity solely in the presence of the dimerizer. They are commonly used to build protein complexes.
This is sometimes a natural process, as is the case with rapamycin, an antifungal compound that binds both FK506-binding protein (FKBP12) and FKBP-rapamycin binding protein (FRB). Another example of a natural dimerizer is gibberellin ...
mTOR inhibitor; immunosuppressant
| Chemical Name: | (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone |
| Purity: | ≥98% (HPLC) |
Chemical inducer of protein dimerization; active in vivo
| Chemical Name: | 2,2'-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate] |
| Purity: | ≥98% (HPLC) |
Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
| Chemical Name: | (R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate |
| Purity: | ≥98% (HPLC) |
Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
| Chemical Name: | (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate |
| Purity: | ≥98% (HPLC) |
Chemical inducer of protein dimerization; active in vivo
| Chemical Name: | 2,2'-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate] |
| Purity: | ≥98% (HPLC) |
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
| Chemical Name: | 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide |
| Purity: | ≥98% (HPLC) |
Inducer of autophagy via interaction of p62 and LC3
| Chemical Name: | 2-[[[3,4-Bis(phenylmethoxy)phenyl]methyl]amino]ethanol hydrochloride |
| Purity: | ≥98% (HPLC) |
