PRKD3/nPKC nu: Small Molecules and Peptides
Protein Kinase D3 (PRKD3), also known as Protein Kinase C nu (PKC nu), is a member of the Protein Kinase D (PKD) protein family. PRKD3/PKC nu is an 890 amino acid (aa) protein with a predicted molecular mass of 100 kDa. The rodent PRKD3/PKC nu orthologs share 96% aa sequence identity with the human protein. Two alternatively spliced isoforms of PRKD3/PKC nu have been identified in humans. PRKD3/PKC nu is a diacylglycerol receptor and a direct substrate of PKC epsilon and PKC eta. It is ubiquitously expressed and present in the cytoplasm, but translocation to the plasma membrane is required for its activation. PRKD3/PKC nu is implicated in intracellular signaling pathways that promote cell proliferation, differentiation, transformation, motility, protein transport, membrane trafficking, cell survival, and apoptosis. It is also implicated in B cell receptor and T cell receptor signaling.
4 results for "PRKD3/nPKC nu Small Molecules and Peptides" in Products
4 results for "PRKD3/nPKC nu Small Molecules and Peptides" in Products
PRKD3/nPKC nu: Small Molecules and Peptides
Protein Kinase D3 (PRKD3), also known as Protein Kinase C nu (PKC nu), is a member of the Protein Kinase D (PKD) protein family. PRKD3/PKC nu is an 890 amino acid (aa) protein with a predicted molecular mass of 100 kDa. The rodent PRKD3/PKC nu orthologs share 96% aa sequence identity with the human protein. Two alternatively spliced isoforms of PRKD3/PKC nu have been identified in humans. PRKD3/PKC nu is a diacylglycerol receptor and a direct substrate of PKC epsilon and PKC eta. It is ubiquitously expressed and present in the cytoplasm, but translocation to the plasma membrane is required for its activation. PRKD3/PKC nu is implicated in intracellular signaling pathways that promote cell proliferation, differentiation, transformation, motility, protein transport, membrane trafficking, cell survival, and apoptosis. It is also implicated in B cell receptor and T cell receptor signaling.
Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)
| Chemical Name: | 9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one |
| Purity: | ≥98% (HPLC) |
Potent protein kinase D (PKD) inhibitor
| Chemical Name: | 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride |
| Purity: | ≥98% (HPLC) |
Protein kinase inhibitor
| Alternate Names: | SF 2370 |
| Chemical Name: | (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester |
| Purity: | ≥98% (HPLC) |
Selective protein kinase D inhibitor
| Chemical Name: | 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one |
| Purity: | ≥98% (HPLC) |
