3 results for "PORCN Inhibitors" in Products
PORCN Inhibitors Products
Porcupine (PORCN) is a membrane bound O-acyltransferase (MBOAT) that is involved in the acylation (palmitoylation) of Wnt proteins. Palmitoylation is essential for Wnt secretion and signaling, with PORCN inhibitors showing efficacy in inhibiting Wnt-driven tumorigenesis.
Palmitoylation is a post-translational modification where fatty acids, such as palmitic acid, are transferred to target proteins. PORCN selectively catalyzes the palmitoylation of Wnt proteins in the endoplasmic reticulum, a ...
PORCN inhibitor; inhibits Wnt processing and secretion
| Chemical Name: | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
| Purity: | ≥98% (HPLC) |
Highly potent PORCN inhibitor
| Chemical Name: | 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide |
| Purity: | ≥99% (HPLC) |
Potent PORCN inhibitor
| Chemical Name: | N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide |
| Purity: | ≥98% (HPLC) |
