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Phospholipase Inhibitors Products

Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.

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10 results for "Phospholipase Inhibitors" in Products

10 results for "Phospholipase Inhibitors" in Products

Phospholipase Inhibitors Products

Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.

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Phospholipase C inhibitor

Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Phospholipase C inhibitor

Phospholipase A2 inhibitor

Alternate Names: Arachidonyl trifluoromethyl ketone
Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one
Phospholipase A2 inhibitor

High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor

Chemical Name: N-(Cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor

Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable

Chemical Name: 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt
Purity: ≥98% (HPLC)
Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable

Selective PC-PLC inhibitor

Chemical Name: O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
Purity: ≥98% (HPLC)
Selective PC-PLC inhibitor

Potent lp-PLA2 inhibitor

Chemical Name: N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide
Purity: ≥98% (HPLC)
Potent lp-PLA2 inhibitor

Potent and selective PLD2 inhibitor

Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Purity: ≥98% (HPLC)
Potent and selective PLD2 inhibitor

Analog of U 73122 (Cat. No. 1268)

Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
Purity: ≥98% (HPLC)
Analog of U 73122 (Cat. No. 1268)

Potent inhibitor of PLD1 and PLD2; CNS penetrant

Chemical Name: 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide
Purity: ≥98% (HPLC)
Potent inhibitor of PLD1 and PLD2; CNS penetrant

Diacylglycerol lipase inhibitor

Alternate Names: U 57908
Chemical Name: O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone
Purity: ≥95% (HPLC)
Diacylglycerol lipase inhibitor
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