VU 0364739 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4171
Potent and selective PLD2 inhibitor
Key Product Details
Description
Potent and selective PLD2 inhibitor
Product Description
VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).Product Specifications
Molecular Weight
482.98
Formula
C26H27FN4O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
CAS Number
1244640-48-9
PubChem ID
46939225
InChI Key
RYLAMDMOILNBKN-UHFFFAOYSA-N
SMILES
O=C(NCCN3CCC(C(NCN4C5=CC(F)=CC=C5)=O)4CC3)C2=CC1=CC=CC=C1C=C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.3 | 100 |
Preparing Stock Solutions
for VU 0364739 hydrochloride
The following data is based on the product molecular weight 482.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.07 mL | 10.35 mL | 20.70 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.07 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lavieri Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J.Med.Chem.
Product Specific Notices for VU 0364739 hydrochloride
For research use only
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