D609

Name: D609
Brand: Tocris Bioscience
SKU: 1437
Rating: 4 (2 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1437

Citations (5)

(2)

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Key Product Details

Description:	Selective PC-PLC inhibitor
Chemical Name:	O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
Purity:	≥98% (HPLC)
Molecular Weight:	266.46

View Full Technical Details for D609

Biological Activity for D609

D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K_i = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC₅₀ = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

Technical Data for D609

M. Wt	266.46
Formula	C₁₁H₁₅OS₂K
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	83373-60-8
PubChem ID	4234241
InChi Key	IGULCCCBGBDZKQ-UHFFFAOYSA-M
Smiles	S=C(S[K])OC1CC2C3CCCC3C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D609

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	26.65	100

Preparing Stock Solutions for D609

The following data is based on the product molecular weight 266.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.76 mL	37.53 mL
5 mM	0.75 mL	3.75 mL	7.51 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for D609

References are publications that support the biological activity of the product.

Adibhatla Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem.Res. 2012 PMID: 22101393
Zhou D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 2001 PMID: 11408530
Amtmann The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 1996 PMID: 9034754
Tschiakowsky Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 1994 PMID: 7532078

Citations for D609 (5)

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Citations are publications that use Bio-Techne products. Selected citations for D609 include:

Pitt et al. (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell. 28:2623
PMID: 28963439
Sovadinova et al. (2015) Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model. J Pharmacol Exp Ther. 10:e0124454
PMID: 26023933
Navratil et al. (2014) Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases. Infect Immun. 82:3299
PMID: 24866789
Pastor et al. (2014) Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res. 55:966
PMID: 24610889
Upham et al. (2009) Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systems. Environ Health Perspect. 117:545
PMID: 19440492

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Customer Reviews for D609 (2)

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great product

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: Hippocampal neuron

100 μM treat 45min

PMID: PMID: 28963439
D609 does not inhibit LPA-induced COX-2 expression

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Osteosarcoma

Human osteosarcoma cells were incubated with 20 μM D609 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. D609 was ineffective against LPA-induced COX-2 expression while other inhibitors showed inhibition.

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