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Phospholipase Inhibitors: Small Molecules and Peptides

Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.

13 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products

Phospholipase Inhibitors: Small Molecules and Peptides

Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.

13 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products

Phospholipase C inhibitor

Phospholipase D inhibitor

Analog of U 73122 (Cat. No. 1268)

Potent and selective PLD2 inhibitor

Potent and selective PLD1 inhibitor

Diacylglycerol lipase inhibitor

Selective PC-PLC inhibitor

Potent lp-PLA2 inhibitor

High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor

Secretory phospholipase A2 (sPLA2) inhibitor

Potent inhibitor of PLD1 and PLD2; CNS penetrant

Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable

Phospholipase A2 inhibitor

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