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Phospholipase Inhibitors: Small Molecules and Peptides
Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.
13 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products
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Phospholipase Inhibitors: Small Molecules and Peptides
Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.
13 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products
Phospholipase C inhibitor
| Chemical Name : | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione |
| Purity : | ≥98% (HPLC) |
Phospholipase D inhibitor
| Chemical Name : | N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride |
| Purity : | ≥98% (HPLC) |
Analog of U 73122 (Cat. No. 1268)
| Chemical Name : | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione |
| Purity : | ≥98% (HPLC) |
Potent and selective PLD2 inhibitor
| Chemical Name : | N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide |
| Purity : | ≥98% (HPLC) |
Potent and selective PLD1 inhibitor
| Chemical Name : | N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide |
| Purity : | ≥98% (HPLC) |
Diacylglycerol lipase inhibitor
| Alternate Names : | U 57908 |
| Chemical Name : | O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone |
| Purity : | ≥95% (HPLC) |
Selective PC-PLC inhibitor
| Chemical Name : | O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate |
| Purity : | ≥98% (HPLC) |
Potent lp-PLA2 inhibitor
| Chemical Name : | N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide |
| Purity : | ≥98% (HPLC) |
High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor
| Chemical Name : | N-(Cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide |
| Purity : | ≥98% (HPLC) |
Secretory phospholipase A2 (sPLA2) inhibitor
| Chemical Name : | 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone |
| Purity : | ≥95% (HPLC) |
Potent inhibitor of PLD1 and PLD2; CNS penetrant
| Chemical Name : | 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide |
| Purity : | ≥98% (HPLC) |
Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable
| Chemical Name : | 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt |
| Purity : | ≥98% (HPLC) |
Phospholipase A2 inhibitor
| Alternate Names : | Arachidonyl trifluoromethyl ketone |
| Chemical Name : | 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one |
