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Pappalysin-2/PAPP-A2 Products
Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.
4 results for "Pappalysin-2/PAPP-A2" in Products
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Pappalysin-2/PAPP-A2 Products
Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.
4 results for "Pappalysin-2/PAPP-A2" in Products
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunoprecipitation, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #242011 |
| Applications : | Immunoprecipitation, Western Blot |
| Source : | NS0 |
| Accession # : | Q9BXP8 |
| Applications : | Enzyme Activity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
