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9 results for "Pappalysin-1/PAPP-A" in Products
Pappalysin-1/PAPP-A Products
Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.
Reactivity:
Human
Assay Range:
0.781-50 ng/mL
Applications:
ELISA
Reactivity:
Human
Details:
Goat IgG Polyclonal
Applications:
WB
Reactivity:
Human
Details:
Mouse IgG1 kappa Monoclonal Clone #9
Applications:
IHC, WB, ELISA
Reactivity:
Human
Details:
Mouse IgG2B Monoclonal Clone #10E1cc
Applications:
WB, ELISA, IP
Reactivity:
Human
Details:
Mouse IgG1 kappa Monoclonal Clone #PAPP A1-24
Applications:
IHC, WB, ELISA
Reactivity:
Human
Details:
Mouse IgG1 kappa Monoclonal Clone #PAPP A 1-1
Applications:
IHC, WB, ELISA
Reactivity:
Human
Details:
Mouse IgG2B Monoclonal Clone #10E2cc
Applications:
ELISA, IP
Reactivity:
Human
Details:
Mouse IgG2A Monoclonal Clone #7A6
Applications:
ELISA, IP
Reactivity:
Human
Details:
Rabbit IgG Kappa Monoclonal Clone #PAPPA/8804R
Applications:
IHC