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Notch-1 Products

Notch proteins (so named for 'notches' in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

35 results for "Notch-1" in Products

Notch-1 Products

Notch proteins (so named for 'notches' in fly wings) are type I transmembrane glycoproteins involved in specifying cell fates and defining boundaries between different cell types during developmental processes. Notch extracellular domains are large, having 34-36 EGF-like repeats followed by three notch/Lin-12 repeats. Notch proteins interact with transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand binding, a series of cleavage events results in the release of the Notch intracellular domain (NICD), which translocates to the nucleus and initiates transcription of Notch-responsive genes. Thus, Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription.

The four mammalian Notch receptors appear to have distinct functions, since they do not compensate for one another in genetic studies. Mutations in Notch receptors also lead to specific developmental disorders. For example, Notch-3 is predominantly expressed in the developing central nervous system of mice. Mutations in Notch-3 in humans cause an autosomal dominant condition called CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). This disorder is characterized by recurrent ischemic strokes at an early age without any underlying vascular risk and progressive dementia.

35 results for "Notch-1" in Products

Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies

WB, Flow, ChIP, CyTOF-ready, ICC
Catalog #: FAB5267G
ICFlow
Catalog #: FAB5267T
ICFlow
Flow, CyTOF-ready
Catalog #: RDC2068
Catalog #: BAM53171
Catalog #: BAF1057
WB
WB
WB, Flow, IHC, Block, CyTOF-ready, ICC
Catalog #: FAB5267R
ICFlow
Bind
Catalog #: FAB5317G
Flow
Catalog #: FAB5267S
ICFlow
Catalog #: FAB5267U
ICFlow
Bind
Catalog #: FAB5317S
Flow
WB, ICC
CyTOF-ready, ICFlow

Notch pathway inhibitor; prevents Notch complex assembly

Catalog #: BAF3647
WB
Catalog #: BAF5267
WB
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