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Norrin Products

Norrin (also called Norrie Disease Protein or NDP) is a secreted regulatory protein, mutations in which cause Norrie disease (X-linked retinal dysplasia). Norrin consists of disulfide-linked homodimers that oligomerize further via disulfide bridges to form higher order oligomers containing up to ten units of 12 kDa each. Molecular modeling studies predict that Norrin assumes a cysteine-knot structure typical for the TGF-beta family. Although Norrin is not related to Wnt family proteins, it functions like a Wnt protein in that it binds with high affinity to the receptor Frizzled-4, requires LDL receptor-related protein (LRP) as a co-receptor, and induces activation of the canonical Wnt signaling pathway.

65 results for "Norrin" in Products

Norrin Products

Norrin (also called Norrie Disease Protein or NDP) is a secreted regulatory protein, mutations in which cause Norrie disease (X-linked retinal dysplasia). Norrin consists of disulfide-linked homodimers that oligomerize further via disulfide bridges to form higher order oligomers containing up to ten units of 12 kDa each. Molecular modeling studies predict that Norrin assumes a cysteine-knot structure typical for the TGF-beta family. Although Norrin is not related to Wnt family proteins, it functions like a Wnt protein in that it binds with high affinity to the receptor Frizzled-4, requires LDL receptor-related protein (LRP) as a co-receptor, and induces activation of the canonical Wnt signaling pathway.

65 results for "Norrin" in Products

BA
WB, IHC, Block
Catalog #: BAF3014
WB
BA
ELISA, ICC/IF, WB
ICC/IF, IHC, WB
IHC, WB
PAGE
Catalog #: NBP1-84769PEP
AC
Catalog #: NBP1-77014PEP
AC
ICC/IF, WB
Catalog #: NBP1-77014F
ELISA, ICC/IF, WB
Catalog #: NBP1-77014FR
ELISA, ICC/IF, WB
Catalog #: NBP1-77014B
ELISA, ICC/IF, WB
ELISA, ICC/IF, WB
ELISA, ICC/IF, WB
ELISA, ICC/IF, WB
Catalog #: NBP1-77014V
ELISA, ICC/IF, WB
Catalog #: NBP1-77014G
ELISA, ICC/IF, WB
ELISA, ICC/IF, WB
Catalog #: NBP1-77014C
ELISA, ICC/IF, WB
ELISA, ICC/IF, WB
ELISA, ICC/IF, WB
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