Sign In / Register
Mineralocorticoid Receptor Antagonists: Small Molecules and Peptides
Mineralocorticoid Receptor (MR) is a member of the nuclear hormone receptor family. Upon binding of ligand (aldosterone or corticosterone) mineralocorticoid receptors translocate to the nucleus and can form either homo or heterodimers. MR dimers bind to the mineralocorticoid response element (AGAACANNNTGTTCT) to regulate gene transcription. There are four known isoforms of MR.
Mineralocorticoid Receptos are expressed in the kidney, gut, brain, pituitary, hypothalamus and heart. MR plays a critical role in regulating electrolyte and fluid balance in the kidney, as well as having specific roles in the central nervous system. The protein is expressed as a 107 kDa nuclear form. MR and glucocorticoid receptors (GR) can cooperatively form heterodimers.
3 results for "Mineralocorticoid Receptor Antagonists Small Molecules and Peptides" in Products
Product Action
Conjugates
Low Endotoxin
Sample Size
Citations
Mineralocorticoid Receptor Antagonists: Small Molecules and Peptides
Mineralocorticoid Receptor (MR) is a member of the nuclear hormone receptor family. Upon binding of ligand (aldosterone or corticosterone) mineralocorticoid receptors translocate to the nucleus and can form either homo or heterodimers. MR dimers bind to the mineralocorticoid response element (AGAACANNNTGTTCT) to regulate gene transcription. There are four known isoforms of MR.
Mineralocorticoid Receptos are expressed in the kidney, gut, brain, pituitary, hypothalamus and heart. MR plays a critical role in regulating electrolyte and fluid balance in the kidney, as well as having specific roles in the central nervous system. The protein is expressed as a 107 kDa nuclear form. MR and glucocorticoid receptors (GR) can cooperatively form heterodimers.
3 results for "Mineralocorticoid Receptor Antagonists Small Molecules and Peptides" in Products
Mineralocorticoid receptor antagonist
| Alternate Names : | SC 9420, Aldactone |
| Chemical Name : | (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone |
| Purity : | ≥98% (HPLC) |
Potent, selective mineralocorticoid receptor antagonist
| Alternate Names : | Oxprenoate potassium |
| Chemical Name : | (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt |
| Purity : | ≥98% (HPLC) |
Selective mineralocorticoid receptor antagonist
| Alternate Names : | Inspra, Epoxymexrenone |
| Chemical Name : | (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester |
| Purity : | ≥99% (HPLC) |
