Spironolactone

Name: Spironolactone
Brand: Tocris Bioscience
SKU: 2968
Price: 77 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2968

Citations (3)

COA / SDS

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Key Product Details

Description:	Mineralocorticoid receptor antagonist
Alternative Names:	SC 9420, Aldactone
Chemical Name:	(7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
Purity:	≥98% (HPLC)
Molecular Weight:	416.57

View Full Technical Details for Spironolactone

Biological Activity for Spironolactone

Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Compound Libraries for Spironolactone

Spironolactone is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Spironolactone

M. Wt	416.57
Formula	C₂₄H₃₂O₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	52-01-7
PubChem ID	5833
InChi Key	LXMSZDCAJNLERA-ZHYRCANASA-N
Smiles	O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Spironolactone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.66	100
	ethanol	20.83	50

Preparing Stock Solutions for Spironolactone

The following data is based on the product molecular weight 416.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	12.00 mL	24.01 mL
5 mM	0.48 mL	2.40 mL	4.80 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for Spironolactone

References are publications that support the biological activity of the product.

Ye Contrasting effects of epler. and spironola. on adrenal cell steroidogenesis. Horm.Metab.Res. 2009 PMID: 18819053
Struthers A comparison of the aldosterone-blocking agents eplernone and spironola. Clin.Cardiol. 2008 PMID: 18404673
Delyani Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 2000 PMID: 10760075

Citations for Spironolactone (3)

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Citations are publications that use Bio-Techne products. Selected citations for Spironolactone include:

Pinheiro et al. (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 124:222
PMID: 27208730
Liu et al. (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain. 7:32
PMID: 24758222
Thai et al. (2013) Effects of acute restraint stress on set-shifting and reversal learning in male rats. Cogn Affect Behav Neurosci. 13:164
PMID: 23055093

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Product Documents for Spironolactone

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Spironolactone, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov