
Klotho Products
The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. Klotho has both membrane-bound and soluble forms; the soluble form predominates and consists of only the first beta-glycosidase-like repeat. Klotho has beta-glucuronidase activity against select steroid beta-glucuronides, appears to regulate calcium and vitamin D levels in serum, and is associated with premature aging.
Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.
8 results for "Klotho" in Products
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Klotho Products
The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. Klotho has both membrane-bound and soluble forms; the soluble form predominates and consists of only the first beta-glycosidase-like repeat. Klotho has beta-glucuronidase activity against select steroid beta-glucuronides, appears to regulate calcium and vitamin D levels in serum, and is associated with premature aging.
Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.
8 results for "Klotho" in Products
Source : | NS0 |
Accession # : | Q9UEF7 |
Applications : | Bioactivity |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA, Immunohistochemistry, Western Blot |
Source : | CHO |
Accession # : | O35082.2 |
Applications : | Bioactivity |
Assay Range : | 78.1 - 5,000 pg/mL |
Applications : | ELISA |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #775340 |
Applications : | Block/Neutralize |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #236214 |
Applications : | ELISA, Immunohistochemistry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Mucin Stalk Chimera
Source : | CHO |
Accession # : | Q9UEF7 (Klotho) & P78423 (Fractalkine Mucin-like S |
Applications : | Bioactivity |