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Integrin alpha 4 beta 1 Products
Integrin alpha 4 beta 1, also known as VLA-4, is an Integrin family adhesion receptor that shares the beta 1 subunit with eleven other family members and the alpha 4 subunit with Integrin alpha 4 beta 7. The noncovalent heterodimer of alpha 4/CD49d and beta 1/CD29 subunits mediates cell adhesion to VCAM-1/CD106 on other cells and the CS-1 fragment of Fibronectin in the extracellular matrix. Leukocytes (except for neutrophils), erythroid precursors, and some non-hematopoietic cells such as epicardial, endothelial and smooth muscle precursors, Schwann cells, and chorionic cells express a4b1. In the adult, a4b1 primarily regulates immune cell migration. Circulating leukocyte a4b1 is rapidly activated by inflamed endothelial cells that present VCAM-1 and chemokines such as CXCL12/SDF-1. This activation facilitates rolling, firm adhesion, and extravasation. During immune cell activation, a4b1 can function as a costimulatory molecule.
21 results for "Integrin alpha 4 beta 1" in Products
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Integrin alpha 4 beta 1 Products
Integrin alpha 4 beta 1, also known as VLA-4, is an Integrin family adhesion receptor that shares the beta 1 subunit with eleven other family members and the alpha 4 subunit with Integrin alpha 4 beta 7. The noncovalent heterodimer of alpha 4/CD49d and beta 1/CD29 subunits mediates cell adhesion to VCAM-1/CD106 on other cells and the CS-1 fragment of Fibronectin in the extracellular matrix. Leukocytes (except for neutrophils), erythroid precursors, and some non-hematopoietic cells such as epicardial, endothelial and smooth muscle precursors, Schwann cells, and chorionic cells express a4b1. In the adult, a4b1 primarily regulates immune cell migration. Circulating leukocyte a4b1 is rapidly activated by inflamed endothelial cells that present VCAM-1 and chemokines such as CXCL12/SDF-1. This activation facilitates rolling, firm adhesion, and extravasation. During immune cell activation, a4b1 can function as a costimulatory molecule.
21 results for "Integrin alpha 4 beta 1" in Products
Catalog #:
6997
Red fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 646; fluorogenic; photostable
| Chemical Name : | 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-5-(((1-((3R,5S)-5-(((S)-1-carboxy-2-(4-((pyrrolidine-1-carbonyl)oxy)phenyl)ethyl)carbamoyl)-1-(phenylsulfonyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)benzoate |
| Purity : | ≥90% (HPLC) |
Catalog #:
5668-A4
BA
| Source : | CHO |
| Accession # : | P13612 (Integrin alpha 4) & P05556 (Integrin beta 1) |
| Applications : | Bioactivity |
Catalog #:
MAB10603
Flow, CyTOF-ready
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | CyTOF-ready, Flow Cytometry |
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
| Chemical Name : | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
| Purity : | ≥98% (HPLC) |
Catalog #:
6996
Yellow fluorescent dual α9β1/α4β1 integrin inhibitor comprising BOP conjugated to Janelia Fluor® 549; fluorogenic; photostable
| Chemical Name : | 2-(3-(Azetidin-1-ium-1-ylidene)-6-(azetidin-1-yl)-3H-xanthen-9-yl)-4-(((1-((3R,5S)-5-(((S)-1-carboxy-2-(4-((pyrrolidine-1-carbonyl)oxy)phenyl)ethyl)carbamoyl)-1-(phenylsulfonyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methyl)carbamoyl)benzoate |
| Purity : | ≥85% (HPLC) |
Catalog #:
FAB10603G
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | Flow Cytometry |
Catalog #:
6048
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
| Chemical Name : | (4R)-4-[4-[[[[4-[3,6-Bis(diethylamino)xanthylium-9-yl]-3-sulfophenyl]sulfonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1-(phenylsulfonyl)-L-prolyl-O-(1-pyrrolidinyl)-L-tyrosine acetate |
| Purity : | ≥97% (HPLC) |
Selective α4β1 (VLA-4) inhibitor
| Purity : | ≥95% (HPLC) |
Catalog #:
3900
α4β1 (VLA-4) antagonist
| Chemical Name : | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
| Purity : | ≥98% (HPLC) |
Catalog #:
6908
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
| Chemical Name : | (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid |
| Purity : | ≥98% (HPLC) |
Catalog #:
10527-A4
BA
| Source : | CHO |
| Accession # : | XP_005573683.1 (Integrin alpha 4) & XP_005564991.1 |
| Applications : | Bioactivity |
Catalog #:
FAB10603R
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | Flow Cytometry |
Catalog #:
DY5668-05
ELISA
| Assay Range : | 125 - 8,000 pg/mL |
| Applications : | ELISA |
Catalog #:
FAB10603N
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | Flow Cytometry |
Catalog #:
FAB10603T
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | Flow Cytometry |
Catalog #:
FAB10603U
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | Flow Cytometry |
Catalog #:
FAB10603V
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | Flow Cytometry |
Catalog #:
FAB10603S
Flow
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu114 |
| Applications : | Flow Cytometry |
Catalog #:
6054-A4
BA
| Source : | CHO |
| Accession # : | AAH68313 (Integrin alpha 4) & P09055 (Integrin beta 1) |
| Applications : | Bioactivity |
