IFN-gamma R2: Proteins and Enzymes

The high-affinity IFN-gamma receptor complex is made up of two type I membrane proteins, IFN-gamma R1 and IFN-gamma R2. Both proteins are members of the type II cytokine receptor family. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for signaling but does not bind IFN-gamma by itself.