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10 results for "Histone Acetyltransferase Inhibitors Small Molecules and Peptides" in Products

Histone Acetyltransferase Inhibitors: Small Molecules and Peptides

Histone Acetyltransferases (HATs; also known as Lysine Aceyltransferases or KATs) are catalytic domains found in a diverse range of proteins; there are 37 endogenous mammalian proteins that are thought to have HAT activity. HAT domains can be found in proteins alongside other epigenetic domains, such as bromodomains, which recognize acetylated lysine residues. Proteins with HAT activity are found in multiprotein complexes, the components of which regulate HAT specificity and integration with ...

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Potent and selective p300/CBP inhibitor; orally bioavailable

Chemical Name: (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide
Purity: ≥98% (HPLC)
Potent and selective p300/CBP inhibitor; orally bioavailable

High affinity KAT6A (MOZ) competitive inhibitor

Chemical Name: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Purity: ≥98% (HPLC)
High affinity KAT6A (MOZ) competitive inhibitor

Lysine acetyltransferase HBO1 (KAT7) inhibitor

Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide
Purity: ≥98% (HPLC)
Lysine acetyltransferase HBO1 (KAT7) inhibitor

Potent p300/CBP inhibitor

Chemical Name: (1'S,3'R)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide
Purity: ≥98% (HPLC)
Potent p300/CBP inhibitor

Inhibitor of KAT5 (Tip60)

Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Inhibitor of KAT5 (Tip60)

Potent and selective KAT6A and KAT6B inhibitor

Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
Purity: ≥98% (HPLC)
Potent and selective KAT6A and KAT6B inhibitor

Reversible and non-competitive CBP/p300 inhibitor

Chemical Name: 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Purity: ≥98% (HPLC)
Reversible and non-competitive CBP/p300 inhibitor

Negative control for iP300w (Cat. No. 7270)

Chemical Name: (1'R,3'S)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide
Purity: ≥98% (HPLC)
Negative control for iP300w (Cat. No. 7270)

Steroid receptor coactivator 3 (SRC-3) inhibitor

Chemical Name: 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Purity: ≥98% (HPLC)
Steroid receptor coactivator 3 (SRC-3) inhibitor

Potent and selective EP300 Degrader (PROTAC®)

Chemical Name: 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)dodecanamide
Purity: ≥98% (HPLC)
Potent and selective EP300 Degrader
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