10 results for "Histone Acetyltransferase Inhibitors Small Molecules and Peptides" in Products
Histone Acetyltransferase Inhibitors: Small Molecules and Peptides
Histone Acetyltransferases (HATs; also known as Lysine Aceyltransferases or KATs) are catalytic domains found in a diverse range of proteins; there are 37 endogenous mammalian proteins that are thought to have HAT activity. HAT domains can be found in proteins alongside other epigenetic domains, such as bromodomains, which recognize acetylated lysine residues. Proteins with HAT activity are found in multiprotein complexes, the components of which regulate HAT specificity and integration with ...
Potent and selective p300/CBP inhibitor; orally bioavailable
| Chemical Name: | (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide |
| Purity: | ≥98% (HPLC) |
High affinity KAT6A (MOZ) competitive inhibitor
| Chemical Name: | 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide |
| Purity: | ≥98% (HPLC) |
Lysine acetyltransferase HBO1 (KAT7) inhibitor
| Chemical Name: | N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide |
| Purity: | ≥98% (HPLC) |
Potent p300/CBP inhibitor
| Chemical Name: | (1'S,3'R)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide |
| Purity: | ≥98% (HPLC) |
Inhibitor of KAT5 (Tip60)
| Chemical Name: | 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole |
Potent and selective KAT6A and KAT6B inhibitor
| Chemical Name: | N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide |
| Purity: | ≥98% (HPLC) |
Reversible and non-competitive CBP/p300 inhibitor
| Chemical Name: | 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione |
| Purity: | ≥98% (HPLC) |
Negative control for iP300w (Cat. No. 7270)
| Chemical Name: | (1'R,3'S)-3'-Fluoro-N-[(4-fluorophenyl)methyl]-2',3'-dihydro-5'-[1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl]-2,5-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[imidazolidine-4,1'-[1H]indene]-1-acetamide |
| Purity: | ≥98% (HPLC) |
Steroid receptor coactivator 3 (SRC-3) inhibitor
| Chemical Name: | 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective EP300 Degrader (PROTAC®)
| Chemical Name: | 12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)-N-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)dodecanamide |
| Purity: | ≥98% (HPLC) |
