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GITR/TNFRSF18: Antibodies

GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a transmembrane TNF receptor superfamily member that functions in immune regulation. GITR is expressed on CD4+CD25+ regulatory T cells (Treg) as well as on subsets of thymocytes, lymph node cells, and splenocytes, and it is upregulated on antigen-activated conventional CD4+ and CD8+ T cells. GITR binding by GITR Ligand/TNFSF18 costimulates the proliferation and activation of CD4+ or CD8+ conventional T cells. It also induces the proliferation of Treg but inhibits the ability of Treg to suppress immune responses. This can result in the development of autoimmunity, increased tumor cell killing by effector T cells, and increased inflammation in arthritis, allergic asthma, and inflammatory bowel disease. GITR is also expressed on sympathetic neurons where it enhances NGF-induced neurite outgrowth and branching.

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223 results for "GITR/TNFRSF18 Primary Antibodies" in Products

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GITR/TNFRSF18: Antibodies

GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a transmembrane TNF receptor superfamily member that functions in immune regulation. GITR is expressed on CD4+CD25+ regulatory T cells (Treg) as well as on subsets of thymocytes, lymph node cells, and splenocytes, and it is upregulated on antigen-activated conventional CD4+ and CD8+ T cells. GITR binding by GITR Ligand/TNFSF18 costimulates the proliferation and activation of CD4+ or CD8+ conventional T cells. It also induces the proliferation of Treg but inhibits the ability of Treg to suppress immune responses. This can result in the development of autoimmunity, increased tumor cell killing by effector T cells, and increased inflammation in arthritis, allergic asthma, and inflammatory bowel disease. GITR is also expressed on sympathetic neurons where it enhances NGF-induced neurite outgrowth and branching.

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223 results for "GITR/TNFRSF18 Primary Antibodies" in Products

WB, Flow, Block, CyTOF-ready
WB, Flow, IHC, Block, CyTOF-ready
Flow, IHC, CyTOF-ready, ICC

Recombinant Monoclonal Antibody.

WB
WB, Flow, CyTOF-ready
WB
Catalog #: FAB5241S
Flow
Catalog #: FAB5241G
Flow
Catalog #: FAB5241N
Flow
Catalog #: FAB5241V
Flow
Catalog #: FAB5241T
Flow
Catalog #: FAB52412N
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB52412U
Flow

Recombinant Monoclonal Antibody.

WB
Flow, IP
Catalog #: FAB5241R
Flow
Catalog #: FAB689T
Flow
Catalog #: MAB524
WB
Flow
IHC, WB
Catalog #: FAB5241U
Flow
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