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Fibroblast Activation Protein alpha/FAP Products
FAP (also known as seprase) is a transmembrane serine protease, and a soluble and enzymatically active form of FAP known as antiplasmin-cleaving enzyme (APCE) circulates in human plasma. FAP is expressed on reactive stromal fibroblasts in tumor tissue and wound healing and on synoviocytes in rheumatoid arthritis. It exhibits dipeptidyl peptidase activity with substrate specificity similar to DPPIV/CD26, which is specific for N-terminal Xaa-Pro sequences. FAP is also an endopeptidase that can degrade Gelatin, Collagens I and IV, Fibronectin, and Laminin as well as several peptide hormones (e.g. Neuropeptide Y, Brain Natriuretic Peptide, Substance P, Peptide YY, and Incretins). The enzymatic activity is dependent on FAP association with DPPIV on the cell surface. The matrix-dedgrading activity of FAP contributes to tumor cell migration and invasion. In addition, FAP can enhance tumor cell growth by limiting the development of anti-tumor immunity.
35 results for "Fibroblast Activation Protein alpha/FAP" in Products
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Fibroblast Activation Protein alpha/FAP Products
FAP (also known as seprase) is a transmembrane serine protease, and a soluble and enzymatically active form of FAP known as antiplasmin-cleaving enzyme (APCE) circulates in human plasma. FAP is expressed on reactive stromal fibroblasts in tumor tissue and wound healing and on synoviocytes in rheumatoid arthritis. It exhibits dipeptidyl peptidase activity with substrate specificity similar to DPPIV/CD26, which is specific for N-terminal Xaa-Pro sequences. FAP is also an endopeptidase that can degrade Gelatin, Collagens I and IV, Fibronectin, and Laminin as well as several peptide hormones (e.g. Neuropeptide Y, Brain Natriuretic Peptide, Substance P, Peptide YY, and Incretins). The enzymatic activity is dependent on FAP association with DPPIV on the cell surface. The matrix-dedgrading activity of FAP contributes to tumor cell migration and invasion. In addition, FAP can enhance tumor cell growth by limiting the development of anti-tumor immunity.
35 results for "Fibroblast Activation Protein alpha/FAP" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | Immunohistochemistry, Immunoprecipitation, Knockout Validated, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | ELISA, Flow Cytometry, Immunocytochemistry/Immunofluorescence |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Source : | CHO |
| Accession # : | XP_005573377 |
| Applications : | Enzyme Activity |
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | ELISA Detection, Western Blot |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983810 |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #427819 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #983802 |
| Applications : | Flow Cytometry |
Simple Plex Human Fibroblast Activation Protein alpha/FAP assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Source : | Sf 21 (baculovirus) |
| Accession # : | Q12884 |
| Applications : | Enzyme Activity |
Control for use with Human Fibroblast Activation Protein alpha/FAP Simple Plex Cartridge Kit
