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ErbB2/Her2 Products

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

91 results for "ErbB2/Her2" in Products

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ErbB2/Her2 Products

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

91 results for "ErbB2/Her2" in Products

Flow, CyTOF-ready, InhibCellGro

Recombinant Monoclonal Antibody For Research Use Only

Potent EGFR PROTAC®; also degrades HER2

Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies

Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies

Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins

Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies

Flow, CyTOF-ready, InhibCellGro

Recombinant Monoclonal Antibody For Research Use Only

WB, Flow, IHC, CyTOF-ready, ICC

Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies

Potent dual specificity EGFR/HER2 inhibitor; active in vivo

WB, Flow, IHC, CyTOF-ready, InhibCellGro
Flow

Simple Plex Human ErbB2/Her2 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

BA

Negative control for PP 2 (Cat. No. 1407)

BA
Flow

Recombinant Monoclonal Antibody For Research Use Only

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