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ErbB2/Her2 Products
ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.
91 results for "ErbB2/Her2" in Products
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ErbB2/Her2 Products
ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.
91 results for "ErbB2/Her2" in Products
Flow, CyTOF-ready, InhibCellGro
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu5 |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry |
Catalog #:
7262
Potent EGFR PROTAC®; also degrades HER2
| Chemical Name : | (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6- yl)phenoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
Catalog #:
SPCK-PANEL
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Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
BA
| Source : | HEK293 |
| Accession # : | P04626-1 |
| Applications : | Bioactivity |
Catalog #:
ARY027
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
Catalog #:
MAB9896
Flow, CyTOF-ready, InhibCellGro
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #H2M5B |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry |
BA
| Source : | NS0 |
| Accession # : | NP_004439 |
| Applications : | Bioactivity |
WB, Flow, IHC, CyTOF-ready, ICC
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #191924 |
| Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot |
Catalog #:
ARY012
Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
Potent dual specificity EGFR/HER2 inhibitor; active in vivo
| Alternate Names : | BIBW2992 |
| Chemical Name : | (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate |
| Purity : | ≥98% (HPLC) |
WB, Flow, IHC, CyTOF-ready, InhibCellGro
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
WB, IHC
| Clonality : | Polyclonal |
| Host : | Sheep IgG |
| Applications : | Immunohistochemistry, Western Blot |
Catalog #:
FAB6744P
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #666521 |
| Applications : | Flow Cytometry |
Flow
| Clonality : | Monoclonal |
| Host : | Rat IgG1 Clone #666521 |
| Applications : | Flow Cytometry |
Catalog #:
SPCKB-PS-000335
Simple Plex Human ErbB2/Her2 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Catalog #:
AFR1129
BA
| Source : | NS0 |
| Accession # : | NP_004439.2 |
| Applications : | Bioactivity |
Negative control for PP 2 (Cat. No. 1407)
| Chemical Name : | 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity : | ≥98% (HPLC) |
Catalog #:
AFG1129
BA
| Source : | NS0 |
| Accession # : | NP_004439.2 |
| Applications : | Bioactivity |
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG2b Clone #191924 |
| Applications : | Flow Cytometry |
Catalog #:
FAB9589P
Flow
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu5 |
| Applications : | Flow Cytometry |
ELISA
| Assay Range : | 54.7 - 3,500 pg/mL |
| Applications : | ELISA |
