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EOMES Products

EOMES (Eomesodermin; Eo from Greek meaning "dawn"/early in mesoderm; also TBR2) is a 72 kDa member of the TBR1 subfamily, T-box family of transcription factors. It is expressed in NK and CD8+ T cells, where CTLA4 activation suppresses EOMES activation of IFN-gamma and granzyme B genes. It is also found in the embryo, where it occurs in forebrain floorplate and migrating neuroblasts at 12.5 weeks gestation. Notably, it is reported to undergo intercellular transfer in fetal Xenopus tissue destined to become mesoderm. Here, it synchronizes a multicellular commitment to a cell lineage. Human EOMES is 686 amino acids (aa) in length. It contains short poly-Ala, -Gly and -Asn motifs, and a DNA-binding T box (aa 276-456). There is one isoform that shows a 19 aa insertion after Ser460. Over aa 471-686, human EOMES shares 91% aa identity with mouse EOMES.

65 results for "EOMES" in Products

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EOMES Products

EOMES (Eomesodermin; Eo from Greek meaning "dawn"/early in mesoderm; also TBR2) is a 72 kDa member of the TBR1 subfamily, T-box family of transcription factors. It is expressed in NK and CD8+ T cells, where CTLA4 activation suppresses EOMES activation of IFN-gamma and granzyme B genes. It is also found in the embryo, where it occurs in forebrain floorplate and migrating neuroblasts at 12.5 weeks gestation. Notably, it is reported to undergo intercellular transfer in fetal Xenopus tissue destined to become mesoderm. Here, it synchronizes a multicellular commitment to a cell lineage. Human EOMES is 686 amino acids (aa) in length. It contains short poly-Ala, -Gly and -Asn motifs, and a DNA-binding T box (aa 276-456). There is one isoform that shows a 19 aa insertion after Ser460. Over aa 471-686, human EOMES shares 91% aa identity with mouse EOMES.

65 results for "EOMES" in Products

WB, CyTOF-ready, ICC, ICFlow
WB, CyTOF-ready, ICC, ICFlow

Recombinant Monoclonal Antibody.

ICC/IF, IHC, IP, WB

Recombinant Monoclonal Antibody

Catalog #: IC6166U
ICFlow
ICFlow
ICFlow

Recombinant Monoclonal Antibody.

ICFlow

Recombinant Monoclonal Antibody.

ICC/IF, IHC, WB
Catalog #: IC6166T
ICFlow
Catalog #: IC6166V
ICFlow
Catalog #: IC6166N
ICFlow
Catalog #: IC6166S
ICFlow
Catalog #: IC6166R
ICFlow
Catalog #: IC8889S
ICFlow

Recombinant Monoclonal Antibody.

Catalog #: IC8889N
ICFlow

Recombinant Monoclonal Antibody.

Catalog #: IC8889T
ICFlow

Recombinant Monoclonal Antibody.

Catalog #: IC8889U
ICFlow

Recombinant Monoclonal Antibody.

Catalog #: IC8889V
ICFlow

Recombinant Monoclonal Antibody.

Catalog #: IC8889R
ICFlow

Recombinant Monoclonal Antibody.

IHC, WB
AP, ELISA, MA, PAGE, WB
AP, ELISA, MA, PAGE, WB
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