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ENPP-2/Autotaxin Products
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine. The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.
13 results for "ENPP-2/Autotaxin" in Products
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ENPP-2/Autotaxin Products
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine. The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.
13 results for "ENPP-2/Autotaxin" in Products
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Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
| Sensitivity : | 0.157 ng/mL |
| Assay Range : | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, Heparin Plasma, Urine, Human Milk) |
| Applications : | ELISA |
Simple Plex Human ENPP-2/Autotaxin assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Source : | NS0 |
| Accession # : | Q9R1E6 |
| Applications : | Enzyme Activity |
Potent and selective autotaxin inhibitor
| Chemical Name : | B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid |
| Purity : | ≥98% (HPLC) |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunoprecipitation, Western Blot |
| Assay Range : | 78.1 - 5,000 pg/mL |
| Applications : | ELISA |
| Source : | NS0 |
| Accession # : | Q13822 |
| Applications : | Enzyme Activity |
