HA 130
Tocris Bioscience, part of Bio-Techne | Catalog # 4196
Potent and selective autotaxin inhibitor
Key Product Details
Description
Potent and selective autotaxin inhibitor
Product Description
HA 130 is a potent and selective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.Product Specifications
Molecular Weight
463.29
Formula
C24H19BFNO5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
B-[3-[[4-[[3-[(4-Fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-boronic acid
CAS Number
1229652-21-4
PubChem ID
46911532
InChI Key
VTNKMYWFWQTEHE-XKZIYDEJSA-N
SMILES
FC1=CC=C(CN3C(/C(SC3=O)=C/C2=CC=C(OCC4=CC(B(O)O)=CC=C4)C=C2)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.33 | 100 |
Preparing Stock Solutions
for HA 130
The following data is based on the product molecular weight 463.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.79 mL | 21.58 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Albers Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc.Natl.Acad.Sci.USA 2010 PMID: 20360563
- Albers Discovery and optimization of boronic acid based inhibitors of autotaxin. J.Med.Chem. 2010 PMID: 20536182
Product Specific Notices for HA 130
For research use only
Loading...
Loading...