ECE-2: Small Molecules and Peptides
ECE-2 is a zinc protease of the neprilysin (NEP) family, which also includes ECE-1, PEX, XCE, DINE, Kell and several NEPlike proteins. ECE-2 is a type II transmembrane protein with a short cytoplasmic tail and a large ectodomain. Three alternatively spliced forms differ in their cytoplasmic tail. In addition to big endothelin-1, ECE-2 cleaves a variety of bioactive peptides such as bradykinin, neurotensin, angiotensin I, substance P, dynorphin B, proenkephalin-derived peptides such as peptide E, BAM22 and BAM18, and PENLEN, an endogenous inhibitor of prohormone convertase 1. Together with ECE-1, it is also involved in degradation of beta-amyloid peptide.
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ECE-2: Small Molecules and Peptides
ECE-2 is a zinc protease of the neprilysin (NEP) family, which also includes ECE-1, PEX, XCE, DINE, Kell and several NEPlike proteins. ECE-2 is a type II transmembrane protein with a short cytoplasmic tail and a large ectodomain. Three alternatively spliced forms differ in their cytoplasmic tail. In addition to big endothelin-1, ECE-2 cleaves a variety of bioactive peptides such as bradykinin, neurotensin, angiotensin I, substance P, dynorphin B, proenkephalin-derived peptides such as peptide E, BAM22 and BAM18, and PENLEN, an endogenous inhibitor of prohormone convertase 1. Together with ECE-1, it is also involved in degradation of beta-amyloid peptide.
Neutral endopeptidase and endothelin converting enzyme inhibitor
| Chemical Name: | N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt |
| Purity: | ≥95% (HPLC) |
