Drebrin 1: Proteins and Enzymes

Drebrin 1, also known as Developmentally-regulated Brain Protein, is a member of the ADF-H family of actin-binding proteins. Human Drebrin 1 is 649 amino acids (aa) in length and shares 82% aa sequence identity with the mouse and rat orthologs. It contains an N-terminal actin depolymerizing homology domain (aa 3-134), an actin-binding region (aa 150-300), and two C-terminal HOMER binding motifs (aa 539-543 and 617-621). It has a predicted molecular weight of approximately 72 kDa, but runs ...