CRTAM: Proteins and Enzymes

CRTAM (Class I-restricted T cell-associated molecule) is a nectin family member of the immunoglobulin superfamily that is expressed by activated CD8⁺ and NK T cells. NK activation receptor engagement, but not cytokines, also induce NK CRTAM expression. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and in brain where it is highly expressed by Purkinje cells of the cerebellum.

Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a ...