Complement Signaling Compounds: Small Molecules and Peptides

The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance.

There are three pathways that can activate the complement system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative complement pathway (spontaneous activation) and the mannose-binding lectin ...