Compstatin

Name: Compstatin
Brand: Tocris Bioscience
SKU: 2585
Rating: 4 (1 reviews)

Catalog # 2585 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (7)

COA / SDS

C3-binding peptide; inhibits complement activation

Key Product Details

Description:	C3-binding peptide; inhibits complement activation
Purity:	≥95% (HPLC)
Molecular Weight:	1550.77

View Full Technical Details for Compstatin

Technical Data
Citations (7) / Reviews (1)

Biological Activity for Compstatin

Compstatin is a complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC₅₀ = 28 μM) and activation of classical and alternative complement pathways (IC₅₀ values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates.

Control Peptide also available.

Technical Data for Compstatin

M. Wt	1550.77
Formula	C₆₆H₉₉N₂₃O₁₇S₂
Single Letter Sequence	ICVVQDWGHHRCT (Modifications: Thr-13 = C-terminal amide, Disulfide bridge: 2-12)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	206645-99-0
PubChem ID	25082538
InChi Key	RDTRHBCZFDCUPW-KWICJJCGSA-N
Smiles	[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CC2=CNC=N2)NC(=O)CNC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Compstatin

Solubility

Soluble to 2mg/ml in water

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References for Compstatin

References are publications that support the biological activity of the product.

Soulika Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 2000 PMID: 10964539
Fiane Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 1999 PMID: 10355733
Sahu Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 1996 PMID: 8752942

Citations for Compstatin (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Compstatin include:

Sharma et al. (2021) Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nat Commun. 12:7293
PMID: 34911940
Larsen et al. (2019) Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG. Front Immunol. 9:3088
PMID: 30666256
Koupenova et al. (2019) The role of platelets in mediating a response to human influenza infection. Nat Commun. 10:1780
PMID: 30992428
Lee et al. (2014) Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes. Cell Death Dis. 5:e1192
PMID: 24763049
Magge et al. (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther. 20:342
PMID: 23661042
Sun et al. (2012) Is asthma related to choroidal neovascularization? Pharmacol Res Perspect. 7:e35415
PMID: 22567103
Yang et al. (2009) Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the IF.-inducible immunoproteasome. Arterioscler Thromb Vasc Biol. 29:1213
PMID: 19443843

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Customer Reviews for Compstatin (1)

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We have tested whether C3b can enzymatically degrade Amyloid Precursor Protein

Name: Ahsan Habib

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: CHO/APPwt

We wanted to investigate whether alpha -secretase like activity in human cord blood serum is mediated by complement C3b enzymatic activity. Compstatin (Cat. No. 2585) pre-incubated in different doses with whole as well as C3 depleted cord blood serum for 15 min at 37°C followed by treatment in CHO/APPwt cells with these premix complexes for 2 h.

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