SB 290157 trifluoroacetate

Product Description

SB 290157 trifluoroacetate is a potent C3a receptor antagonist (IC₅₀ values are 27 - 30 nM for C3a-induced Ca²⁺ mobilization in vitro and ex vivo). Inhibits C3a-induced chemotaxis in human mast cell line. Also inhibits tau hyperphosphorylation in vitro. Displays anti-inflammatory effects in animal models of airway inflammation and arthritis. Also inhibits glucose-induced insulin secretion and ATP production from ex vivo human and mouse pancreatic islets. Also exhibits C3a receptor agonist activity.

Solubility

Preparing Stock Solutions for SB 290157 trifluoroacetate

The following data is based on the product molecular weight 526.51

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.50 mL	18.99 mL
5 mM	0.38 mL	1.90 mL	3.80 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mathieu The C3a receptor antagonist SB 290157 has agonist activity. Immunol.Lett. 2005 PMID: 16154494
• Atanes C3aR and C5aR1 act as key regulators of human and mouse β-cell function. Cell Mol.Life Sci. 2018 PMID: 28921001
• Hu Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways. Eur.J.Pharmacol. 2019 PMID: 30771350
• Ames Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J.Immunol. 2001 PMID: 11342658