COCO: Proteins and Enzymes

COCO is a member of the DAN Domain family of BMP antagonists that includes DAN, Gremlin, PRDC, and Cerberus 1. DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. COCO binds and inhibits Xnr1, BMP-4, activin, and Wnt8. COCO may cooperate with Nodal in gastrulation and embryonic left-right axis formation