Coagulation Factor VII: Proteins and Enzymes

Coagulation Factor VII is synthesized in the liver and circulates in the plasma where it binds to tissue factor (TF), an integral membrane protein found in a variety of cell types. The predominant splicing variant of factor VII in normal liver corresponds to the 444 amino acid precursor. After a signal peptide (residues 1 to 38), the mature chain can be further processed into the light chain (residues 39 to 190) and the heavy chain (residues 191 to 444).