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cIAP-1/HIAP-2 Products
Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibit caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and cIAP-2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi.
10 results for "cIAP-1/HIAP-2" in Products
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cIAP-1/HIAP-2 Products
Cellular inhibitor of apoptosis protein1 (cIAP-1, also known as BIRC2, MIHB, and HIAP2) and 2 (cIAP-2, also known as BIRC3, MIHC, and HIAP1), are members of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. Structurally, cIAP-1 and cIAP-2 are each comprised of 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). Human cIAP-1 and cIAP-2 share 70% sequence identity. Functionally, cIAPs inhibit caspases through the direct interaction of its BIR domain with the active caspase. The ring finger domain of cIAP-1 and cIAP-2 also functions as an E3 ubiquitin ligase to ubiqutinylate specific target proteins. Caspase activity may be restored by mitochondrial proteins, such as SMAC/Diablo or HtrA2/Omi, through interactions with the Reaper-like motif and the BIR domain. cIAPs are reported to be cleaved by HtrA2/Omi.
10 results for "cIAP-1/HIAP-2" in Products
Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Knockout Validated, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #681732 |
| Applications : | Knockout Validated, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG2a Clone #315301 |
| Applications : | Simple Western, Western Blot |
IAP and XIAP inhibitor; antitumor
| Chemical Name : | 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol |
| Purity : | ≥98% (HPLC) |
| Source : | E. coli |
| Accession # : | Q13490 |
| Applications : | Inhibition Activity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #681724 |
| Applications : | Immunohistochemistry |
Dimeric Smac mimetic; potent IAP inhibitor
| Chemical Name : | 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide |
| Purity : | ≥97% (HPLC) |
